NanoBiotechnology and Nano-scale and Micron-scale Devices

Nano-biotechnology is a new field, lying at the convergence of biotechnology and nanotechnology, which integrates biomaterials and synthetic materials to prepare novel nano-scale and micron-scale materials, devices and processes. Such a combination is often made at the molecular scale in the creation of new hybrid molecules, bio-coated nanomaterials, bio-nanocomposites, or supramolecular assemblies.


The primary goals of the fabrication and operation of artificial organelles are to create reaction vessels for the construction of biologically significant products and to employ such a platform to gain a fundamental understanding of organelle structure and function. Digital microfluidics facilitates open droplet movement across a 2D grid-like surface by the process of electrowetting. This technology has opened up new opportunities to design nanoscale biomimetic droplet vesicle-based reaction systems. These systems can be used to mimic the natural fluid vesicles that operate in organelles.

Microarray technology offers a spatially addressable array in a compact format. Cell based micro array technology allows the printing of viable cells in micron-sized hemispherical gel matrices. These cells can then be exposed to chemical or biological substances and probed with stains and antibodies or to monitor their functional state.

As nanoscale materials make their way into medical applications, biocompatibility is an important issue that needs to be resolved. Nanomaterials may one day serve as the building blocks for nanobots and nanomachines that perform medical functions within the body. We are interested in better understanding the nano-bio interface and the preparation of functional bio and blood compatible nano-scale devices. Nano-bio composites are being prepared by molecularly combine synthetic and biological materials in defined geometries with a wide variety of useful structural and biological properties.

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